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Inhibition of PI3K/Akt/mTOR signaling pathway enhances the sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin in vitro

  
@article{CJCR4828,
	author = {Yunlang Cai and Xiaoqiang Tan and Jun Liu and Yang Shen and Di Wu and Mulan Ren and Peilin Huang and Dandan Yu},
	title = {Inhibition of PI3K/Akt/mTOR signaling pathway enhances the sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin in vitro},
	journal = {Chinese Journal of Cancer Research},
	volume = {26},
	number = {5},
	year = {2014},
	keywords = {},
	abstract = {The activation of the PI3K/AKT/mTOR pathway plays a key role in ovarian cancer tumorigenesis, progression and chemotherapy resistance. This study aimed to explore the possible mechanism that PI-103, a dual inhibitor of phosphatidylinositide 3-kinase and mTOR, enhances the sensitivity of SKOV3/DDP ovarian cancer cell line to cisplatin chemotherapy. The results showed that PI- 103 could significantly increase the sensitivity of SKVO3/DDP cells to cisplatin through inhibiting the activation of PI3K/Akt/mTOR signaling pathway and inducing cell cycle arrest and apoptosis.},
	issn = {1993-0631},	url = {http://cjcr.amegroups.com/article/view/4828}
}