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Deletion and down-regulation of SMAD4 gene in colorectal cancers in a Chinese population

  
@article{CJCR4877,
	author = {Yanling Ma and Fei Yan and Li Li and Li Liu and Jianhai Sun},
	title = {Deletion and down-regulation of  SMAD4  gene in colorectal cancers in a Chinese population},
	journal = {Chinese Journal of Cancer Research},
	volume = {26},
	number = {5},
	year = {2014},
	keywords = {},
	abstract = {Objective: Colorectal cancer (CRC) is one of the most common types of human cancers. As a tumor suppressor, SMAD4 plays a key role in colorectal carcinogenesis and invasiveness. Copy number variations (CNVs) of the SMAD4 gene have been reported to be associated with cancer pathogenesis in array-based studies in different populations. Here we aimed to investigate the CNVs of the SMAD4 gene in a relatively large number of CRC patients from China. 
Methods: In the present study, we collected 147 Chinese CRC tumors as well as self-paired normal control tissues. Quantitative PCR was carried out to examine the copy number as well as the mRNA expression of the SMAD4 gene. 
Results: Our results showed that the copy number deletions of SMAD4 were frequent in a relatively high percentage of CRC samples (34.7%, 51 out of 147). There was a positive correlation between the copy number decrease of SMAD4 and tumor progression in CRCs. Furthermore, copy number loss of SMAD4 was correlated with decreased mRNA expression. 
Conclusions: These findings suggested that the copy number deletions of SMAD4 were frequent in CRC patients from China and had the potential to serve as a diagnostic indicator, alone or in combination with other markers, for CRC.},
	issn = {1993-0631},	url = {http://cjcr.amegroups.com/article/view/4877}
}