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Targets and molecular mechanisms of triptolide in cancer therapy

	author = {Cuicui Meng and Hongcheng Zhu and Hongmei Song and Zhongming Wang and Guanhong Huang and Defan Li and Zhaoming Ma and Jianhua Ma and Qin Qin and Xinchen Sun and Jianxin Ma},
	title = {Targets and molecular mechanisms of triptolide in cancer therapy},
	journal = {Chinese Journal of Cancer Research},
	volume = {26},
	number = {5},
	year = {2014},
	keywords = {},
	abstract = {Triptolide (TPL/TL) is a natural drug with novel anticancer effects. Preclinical studies indicated that TPL inhibits cell proliferation, induces cell apoptosis, inhibits tumor metastasis and enhances the effect of other therapeutic methods in various cancer cell lines. Multiple molecules and signaling pathways, such as caspases, heat-shock proteins, NF-κB, and deoxyribonucleic acid (DNA) repair-associated factors, are associated with the anti-cancer effect. TPL also improves chemoradiosensitivity in cancer therapy. Phase I trials indicate the potential clinical value of TPL use. However, further trials with larger sample sizes are needed to confirm these results.},
	issn = {1993-0631},	url = {}