@article{CJCR916,
author = {Xiang-sheng Xiao and Mu-yan Cai and Jie-wei Chen and Xin-yuan Guan and Hsiang-fu Kung and Yi-xin Zeng and Dan Xie},
title = {High Expression of p300 in Human Breast Cancer Correlates with Tumor Recurrence and Predicts Adverse Prognosis},
journal = {Chinese Journal of Cancer Research},
volume = {23},
number = {3},
year = {2012},
keywords = {},
abstract = {Objective: Transcriptional coactivator p300 has been shown to play a variety of roles in the transcription process and mutation of p300 has been found in certain types of human cancers. However, the expression dynamics of p300 in breast cancer (BC) and its effect on BC patients’ prognosis are poorly understood.
Methods: In the present study, the methods of tissue microarray and immunohistochemistry (IHC) were used to investigate the protein expression of p300 in BCs. Receiver operating characteristic (ROC) curve analysis, Spearman’s rank correlation, Kaplan-Meier plots and Cox proportional hazards regression model were utilized to analyze the data.
Results: Based on the ROC curve analysis, the cutoff value for p300 high expression was defined when the H score for p300 was more than 105. High expression of p300 could be observed in 105/193 (54.4%) of BCs, in 6/25 (24.0%) of non-malignant breast tissues, respectively (P=0.004). Further correlation analysis showed that high expression of p300 was positively correlated with higher histological grade, advanced clinical stage and tumor recurrence (P},
issn = {1993-0631}, url = {https://cjcr.amegroups.org/article/view/916}
}