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Neoadjuvant chemotherapy for locally advanced cervical cancer

	author = {Takashi Iwata and Azumi Miyauchi and Yukako Suga and Hiroshi Nishio and Masaru Nakamura and Akiko Ohno and Nobumaru Hirao and Tohru Morisada and Kyoko Tanaka and Hiroki Ueyama and Hidemichi Watari and Daisuke Aoki},
	title = {Neoadjuvant chemotherapy for locally advanced cervical cancer},
	journal = {Chinese Journal of Cancer Research},
	volume = {0},
	number = {0},
	year = {2015},
	keywords = {},
	abstract = {Neoadjuvant chemotherapy followed by surgery (NCS) has not been fully evaluated clinically. Currently, the main regimen of neoadjuvant chemotherapy (NAC) used in NCS includes cisplatin. The antitumor effects of NAC reduce lymph node metastasis and the tumor diameter in patients prior to surgery, and this can reduce the number of high risk patients who require postoperative radiation therapy. Many randomized controlled trials (RCTs) have examined the long-term prognosis of NCS compared to primary surgery, but the utility of NCS remains uncertain. The advent of concurrent chemoradiotherapy (CCRT) has markedly improved the outcome of radiotherapy (RT), and CCRT is now used as a standard method in many cases of advanced bulky cervical cancer. NCS gives a better treatment outcome than radiation therapy alone, but it is important to verify that NCS gives a similar or better outcome compared to CCRT.},
	issn = {1993-0631},	url = {}