TY - JOUR AU - Xing, Tianying AU - He, Huiying PY - 2016 TI - Epigenomics of clear cell renal cell carcinoma: mechanisms and potential use in molecular pathology JF - Chinese Journal of Cancer Research; Vol 28, No 1 (February 29, 2016): Chinese Journal of Cancer Research Y2 - 2016 KW - N2 - Clear cell renal cell carcinoma (ccRCC) is one frequent form of urologic malignancy with numerous genetic and epigenetic alterations. This review summarizes the recent major findings of epigenetic alterations including DNA methylation, histone modifications, microRNAs and recently identified long noncoding RNAs in the development and progression of ccRCC. These epigenetic profilings can provide a promising means of prognostication and early diagnosis for patients with ccRCCs. With the developed high-throughput technologies nowadays, the epigenetic analyses will have possible clinical applications in the molecular pathology of ccRCC. UR - https://cjcr.amegroups.org/article/view/9351